Macau does not have many night club options compared to the increasing number of hotels and casinos. If you are in Macao and would like to go clubbing then we would recommend checking out Club Cubic. This club is a large place and has two rooms, the smaller one is bigger than most Hong Kong clubs! The main room of Cubic is great for live peformances and DJs that they have happening every week.
The other club we would recommend is Divino. They have one main room with balconys where dancers are on the stage each night.
Do check them all out, they are a taxi ride away from each other.